时间: 2019-07-30 作者: 浏览次数: 1

Title: Sodium channel resurgent currents and pain

Time: Thursday afternoon , August 6,2019

Venue: Room 401-1500, Institute of Neuroscience, Soochow University

Host:Prof. Tong Liu


       Wu Bin, Ph.D.,is a visiting scholar at Indiana University School of Medicine.In 2010, he graduated from the School of Life Sciences of Shanghai University. In 2017, he received his Ph.D. from the School of Life Sciences of Shanghai University. From December 2016 to the present, he is a visiting scholar at Indiana University School of Medicine.The research direction of the doctoral period is as follows: 1. The pharmacological modulation and molecular recognition mechanism of the scorpion venom peptide BmP02 on voltage-gated potassium channels 2. The recognition mechanism of Martentoxin on the neuronal BK channel and voltage-gated potassium channel 3. Smooth muscle type BK Effect of glycosylation of channel β1 subunit on channel function and pharmacological properties 4. The effect of cytoplasmic membrane microenvironment changes on the electrophysiological and pharmacological properties of voltage-gated sodium channels.The current research directions is as follows : 1. The peripheral mechanism of neuropathic pain caused by the chemotherapy drug oxaliplatin 2. The analgesic effect and mechanism of coumarin compounds on neuropathic pain.3. The function of revived sodium current in the inflammatory pain model.What’s more,he is familiar with a variety of molecular biology, cell culture, electrophysiology, bioinformatics, animal behavior, data analysis and mapping technologies and operations.


Published papers:

1. B Wu, JS McDermott, JL Krajewski, KL Knopp, ES Nisenbaum, TR Cummins, ZY Tan. Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons. Mol Pain. 2019 Jan-Dec;15.

2. B. Wu, Y. Zhu, J Shi, J Tao, YH Ji. BmP02 Atypically Delays Kv4.2 Inactivation: Implication for a Unique Interaction between Scorpion Toxin and Potassium Channel. Toxins (Basel). 2016 Sep 27;8(10).

3. B Wu, BF Wu, YJ Feng, J Tao, YH Ji. Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel. Sci Rep. 2016 Jul 11;6:29431.

4. Z.W. Li, B. Wu, P. Ye, Z.Y. Tan, Y.H. Ji. Brain natriuretic peptide suppresses pain induced by BmK I, a sodium channel-specific modulator, in rats. J Headache Pain. 2016 Dec;17(1):90.

5. Y. Zhu, B. Wu, Y.J. Feng, J. Tao, Y.H. Ji. Lipid bilayer modification alters the gating properties and pharmacological sensitivity of voltage-gated sodium channel. Acta Physiologica Sinica. 2015 Jun 25;67(3):271-82.

6. J. Tao, Z.L. Zhou, B. Wu, J. Shi, X.M. Chen. Recombinant expression and functional characterization of martentoxin: a selective inhibitor for BK channel (α + β4). Toxins (Basel). 2014 Apr 22;6(4):1419-33.